The medication targets appetite regulation and glucose metabolism in the brain and gut, leaving the testicular tissue and hormonal signaling responsible for reproductive health largely unaffected
SGLT2 Inhibitor and GLP-1 receptor agonist combination therapy substantially improved the renal function in a patient with type 2 diabetes: implications for additive renoprotective effects of the two drug classes
As obesity and insulin resistance are closely tied, this mechanism addresses root causes rather than symptomsmaking it especially valuable for patients with metabolic syndrome or prediabetes
Because media coverage often highlights potential risks, many patients ask whether these medications increase cancer risk
Data availability Details of the search strategy and list of identified articles can be found at Abbreviations BGM: Blood glucose monitoring CGM: Continuous glucose monitoring CSII: Continuous subcutaneous insulin infusion CVOT: Cardiovascular outcomes trial DKA: Diabetic ketoacidosis DPP-4i: Dipeptidyl peptidase-4 inhibitors DSMES: Diabetes self-management education and support ETD: Estimated treatment difference GIP: Glucose-dependent insulinotropic polypeptide GLP-1 RA: Glucagon-like peptide-1 receptor agonist(s) HF: Heart failure HHF: Hospitalisation for heart failure MACE: Major adverse cardiovascular events MNT: Medical nutrition therapy NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis SGLT1i: Sodiumglucose cotransporter-1 inhibitor SGLT2i: Sodiumglucose cotransporter-2 inhibitor(s) TZD: Thiazolidinedione UACR: Urinary albumin/creatinine ratio References Rodriguez-Gutierrez R, Gionfriddo MR, Ospina NS et al (2016) Shared decision making in endocrinology: present and future directions
Samms RJ, Coghlan MP, Sloop KW (2020) How may GIP enhance the therapeutic efficacy of GLP-1
