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3-PH can obtain an amino group from glutamate and form 3-phosphoserine (3-PS) through phosphoserine transaminase (PSAT) followed by dephosphorylation through serine phosphatase (PSPH) to finally produce serine (Figure 1)

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DIAGNOSTIC CRITERIA Using Rome III diagnostic criteria, the disorder has been estimated to have an annual community prevalence of 0.2% to 1.0% [1, 2, 3]

Understanding the functional groups is crucial since pKa values are largely determined by the type of functional group present

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