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Ferritin accumulation in dystrophic microglia is an early event in the development of Huntingtons disease

Key structural characteristics include: The peptide exhibits remarkable stability compared to many bioactive peptides, remaining active in gastric acid conditions and showing resistance to enzymatic degradation, making it suitable for diverse experimental applications

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10.1126/science.1171498 Science 134 OkamotoK.BoschM.HayashiY

2026;e10628

That is the mechanistic reason the two peptides are co-formulated and, as the next section explains, it is also why the short no-DAC form of CJC-1295 is the version chosen for the blend