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Pathologically, ALS is characterized by motor neuron degeneration and a constellation of co-occurring molecular abnormalities, including excitotoxicity, mitochondrial dysfunction, oxidative stress, necrosis, altered proteostasis, impaired cytoskeletal trafficking, DNA damage, and dysfunctional RNA metabolism
Mercury from fish It has been shown that the amount of mercury excretion through urine is proportionate to the amount of fish eaten in a diet
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610,611 These findings reveal how these highly structured and complex RNA motifs harness the conformational ensemble to stabilize distinct ligand-bound forms of the RNA, thus enhancing the affinity of what would otherwise be weak coordinate-covalent bonds
