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ME2 can generate NADPH by converting mitochondrial matrix pool of malate into pyruvate that can reenter the TCA cycle

Preclinical data in rodent models showed approximately 37% greater hepatic fat reduction versus tirzepatide-equivalent dosing, a finding cited in multiple human trial design rationales as justification for the Retatrutide vs Tirzepatide superiority hypothesis in hepatic metabolic disease contexts

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Furthermore, glutamine-derived glutathione production was sustained under hypoxia as a coping method under high ROS levels [39]

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10.3390/ijms25052667 43 GaoK.ZhangJ.GaoP.WangQ.LiuY.LiuJ.et al (2020)