Although these stages are presented as an orderly progression, clinically that is not always the case
This is supported by translational data indicating that blocking nitro-oxidative stress, inflammatory and neurotoxic pathways with selective antioxidative compouds may alleviate depressive-, anxiety-, and chronic fatigue-like behaviors [25, 26, 30, 35,36,37,38,39,40]
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However, this may not be quite that easy
In other embodiments, the formulation or composition provides a therapeutically effective amount of at least one otic therapeutic agent at the site of disease with little or no detectable systemic exposure