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The widespread distribution and function of multiple GLP-1 receptor populations in the central and autonomic nervous system provide the anatomical foundation for the appetite-suppressing effects observed with GLP-1 agonist therapy

2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018

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Primarily, CHAC1 is transcriptionally regulated by ATF4, a key player in the integrated stress response (ISR), which is activated during conditions like amino acid deprivation and oxidative stress (Xu Y