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Jardine MJ, Mahaffey KW, Neal B et al (2017) The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study rationale, design, and baseline characteristics

It seems like both things can be true at once: there is risk of misuse, and there may also be biologically meaningful signals worth rigorously studying

For better and for worse, because I think too much regulation sometimes can be problematic when its not well intentioned and then you have the downside, but the downside of that is that I could release a supplement tomorrow that had a toxic dose of copper in it and that would be permitted by the FDA and FTC currently

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Peripheral Oxyntomodulin Reduces Food Intake and Body Weight Gain in Rats