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Researchers discovered an antioxidant, glutathione, that cancer cells appear to be "addicted to" as fuel, opening new pathways for investigation and a potential drug that can restrict the way tumors use this nutrient

doi: 10.1007/s11682-018-0029-4 48 ZeinehMMKangJAtlasSWRamanMMReissALNorrisJLet al

Indeed, we found a similar mitochondrial response to pemetrexed treatment in three independent KRAS mutant non-small cell lung cancer cell lines (Extended Data Fig

In fact, NADH is an inhibitor of the TCA enzyme isocitrate dehydrogenase 93 , a protective mechanism to prevent overloading of the ETC and excessive ROS generation

Correlation analysis was performed using R software (version 4.1.2, The R Foundation for Statistical Computing, Gut microbiome analyses Fecal samples were collected from WT mice ( n = 5) and Nrf2-KO mice ( n = 10) from the same litter, all of which had not been exposed to noise

That's where glutathione is different