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Controlled endocrine investigations demonstrate stable cortisol or corticosterone concentrations despite measurable growth hormone pulses, supporting limited hypothalamic-pituitary-adrenal axis engagement in experimental models

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GLP-1 agonists can be valuable for selected patients, particularly those with obesity and metabolic comorbidities, but long-term PCOS care should remain holistic combining metabolic management with mental health support, lifestyle sustainability, reproductive health, and patient education

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