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Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal

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When activated, AMPK can indirectly or directly reduce the phosphorylation level of PI3K or prevent the activation of AKT to inhibit the activity of the PI3K/AKT pathway, thereby interfering with various malignant phenotypes of glioma stem cells, including proliferation, migration, invasion, and resistance to apoptosis (93)

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Zhu M, Dagah OMA, Silaa BB, Lu J (2023) Thioredoxin/glutaredoxin systems and gut microbiota in NAFLD: interplay, mechanism, and therapeutical potential