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Despite these changes, food intake, energy expenditure, respiratory quotient, ambulatory activity and leptin sensitivity were not affected in these mice (Supplementary Fig

Furthermore, by using a luciferase reporter system with a UGA codon inserted in the protein coding region of the luciferase reporter gene, we confirmed that selenium-dependent expression was independent of the GPx1 promoter [68]

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The effect of GLS1 knockdown in GBM cells exometabolome was assessed by 1 H-NMR analysis of the conditioned media (extracellular metabolites)