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It acts as a cofactor in the glyoxalase system and helps to detoxify methylglyoxal in step-by-step reactions involving two enzymes viz

Current treatment paradigms and emerging therapies for NAFLD/NASH

In summary, SCLA1, SCLA2 and SCLA3 induced ferroptosis, which correlated with the identification of GPX4 as a target for these SCLAs in pulldown experiments and senescence selectivity of engagement with these SCLAs

Glutathione-mediated detoxification systems in plants

It has been proposed that overexpression of GPX8 reduces Ca 2+ storage and histamine-induced Ca 2+ release in the endoplasmic reticulum (Yoboue et al., 2017)

Furthermore, FoxO3a can bind to PINK1 and Parkin gene promoter and upregulate their expression to enhance mitophagy (Zheng et al., 2019