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intracellular), and certain signaling pathways [34, 35]
By reassessing these systems through the lens of modern peptide pharmacology and systems biology, this review seeks to distinguish between failed biology and failed pharmacology, identify the classes of peptides most amenable to renewed development, and articulate principles that can guide future discovery efforts
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After stirring the reaction mixture at room temperature for 48 h, the product was separated by centrifugation
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