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Peripheral neuropathy applications including diabetic neuropathy, chemotherapy-induced neuropathy, and traumatic nerve injuries represent potential indications based on demonstrated nerve regeneration enhancement in animal models

The rs2016347 SNP is also located in the 3 UTR of IGF-1R and in silico analysis predicted a functional role through transcriptional regulation and possibly miRNA binding

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1 When these receptors are activated by bile acids, they turn on metabolic pathways involved in reducing inflammation, metabolism, and detoxification, including the detoxification of estrogen 5 to keep estrogen balanced

Besouw MT, Bowker R, Dutertre JP, Emma F, Gahl WA, Greco M, Lilien MR, McKiernan J, Nobili F, Schneider JA, Skovby F, van den Heuvel LP, Vant Hoff WG, Levtchenko EN (2011) Cysteamine toxicity in patients with cystinosis