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Personal or family history of multiple endocrine neoplasia (MEN) syndrome

But studies are needed to prove whether GLP-1s improve RA symptoms and disease activity, says Karacabeyli

muscle changes

Rather, GLP-1 receptor activation results in cell growth, and the enzyme release may simply reflect adaptive growth instead of an inflammatory response

Specific conditions may prevent semaglutide usage, such as family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2