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A few commenters stated they were encouraged by our comment solicitation and shared how they believe clinical practices may rely on information to form clinical judgments about using such digital tools and whether such use may be warranted and beneficial to patient care

Foodderived bioactive peptides (e.g., hydrophobic residues like tyrosine, proline, leucine) and synthetic agents (Selank, PT141, GHKCu) can modulate the HPA axis, gutbrain communication, and neuroinflammation, thereby reducing anxiety and improving sleep quality

Front Pharmacol 9:1371 Lee N, Carlisle AE, Peppers A, Park SJ, Doshi MB, Spears ME, Kim D (2021) xCT-driven expression of GPX4 determines sensitivity of breast cancer cells to ferroptosis inducers

N-acetylcysteine (NAC): impacts on human health

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