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In another study, when comparing T1D C-peptide positive pre-pubertal children and adults vs their C-peptide negative counterparts, patients with a residual -cell function had higher IGF-I levels despite similar glycemic control (47, 48)

The relative risk (RR) was estimated using a random-effects model

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These are typically mild and subside over time

This oxidation stress leads to skin aging, formation of wrinkles and fine lines and dull complexion