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Peptides like epialin are interesting because they target DNA repair, rather than just working on downstream receptors or vague targets, which is similar to the concept of gene therapy 2m6s

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However, it is not suitable for everyone and is only recommended for patients with a BMI of 27 or more or those with type 2 diabetes and clinically-diagnosed obesity

The guide RNA of the CRISPR system may mismatch with similar sequences in the genome, leading to off-target integration [167]