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Combined with the increased lipolysis (fat breakdown) and thermogenesis (fat burning), the net effect on body composition is more favorable than what either GLP-1 or GIP agonism can produce alone

How Retatrutide Achieves Its Long Half-Life Retatrutide's extended half-life results from fatty-acid acylation, a chemical modification that allows the molecule to bind to albumin -- the most abundant protein in blood plasma