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ANNEX REGULATION MC3R/MC5R MC3R energetic & MC5R glandular The hypothalamic MC3R participates in energy regulation and adipose metabolism

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Biologic therapies effectively target specific inflammatory mediators, but do not directly address metabolic dysfunction or oxidative stress, both of which contribute to HS severity

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Engelmann C, Clria J, Szabo G, Bosch J, Bernardi M