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80,97,98,99,100,101 A detailed history taking identifies symptoms related to sensory, motor, and autonomic dysfunction, while a physical examination focuses on sensory and motor deficits, and reflex abnormalities

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Moreover, reports demonstrated that glutamate decreased the expression of p-GSK-3, which would increase GSK-3 activity during glutamate-induced neurotoxicity 24

Many edible and medicinal plants can improve DKD through protecting renal mitochondrial function, regulating ERS, anti-inflammation, reducing oxidative stress, and protecting podocytes