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Hsieh MJ et al
Clinical evidence remains limited and outcomes vary by patient
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Outcome : 70% symptom reduction by week 4, returned to baseline by week 8
This capacity of FcRn antagonists to modulate the pharmacokinetics of other IgG-based Ab therapeutics was investigated in a phase I clinical trial (NCT04973566) addressing the effect of nipocalimab on the pharmacokinetics of the IgG Fc-fusion etanercept, which consists of the extracellular domains of tumor necrosis factor-alpha receptor 2 fused to an IgG1 Fc
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