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Disc degeneration is characterized by oxidative-stress-driven apoptosis (cell death) and senescence (cell aging) of nucleus pulposus mesenchymal stem cells

10.1016/j.neuropharm.2008.01.013 266 SikichL.KolevzonA.KingB

L.CarneiroF.MachadoJ

Effects of polyhalogenated aromatic hydrocarbons and related contaminants on common tern reproduction: integration of biological, biochemical, and chemical data

PS-MP exposure led to a marked increase in ovarian COL3A1 and SMAD2 protein expression, along with a significant decrease in SMAD7 protein levels, suggesting activation of fibrotic signaling in the ovary

(1) F-actin formation is considered a key component in the cell's cytoskeleton, providing structure and aiding in cell movement