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Numerous cell signaling pathways are involved in the initiation and progression of cancer cachexia, including the TNF- pathway, TGF/p38/MAPK pathway, NFB pathway, IL-6 pathway, IGF/Akt pathway and FOXO1/FOXO3a pathway, among others [44]

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Taken together, our study highlights the essential role of endothelial IGF- 1R signaling in skeletal muscle vascular health and function