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Preclinical studies on anti-bone sclerosis protein antibodies have shown potential for regulating bone metabolism, but cardiovascular risks have limited clinical translation, necessitating the urgent design of new strategies for safety optimization targeted at the CKD-MBD population (117119)

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Increases in plasma conjugated bilirubin lead to tea-colored urine, because conjugated bilirubin is water soluble

doi: 10.1038/s41392-022-01245-y 43

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