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In 2025, Novo Nordisk swapped longtime CEO Lars Fruergaard Jorgensen with Maziar Mike Doustdar amid slowing momentum and share-price pressure

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For chronic weight management, the FDA-approved indications generally include adults with a BMI of 30 or greater, or BMI 27 or greater with at least one weight-related condition (type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease)

GLP-1 is what is known as a glucagon-like peptide-1 (GLP-1) receptor agonist, acting in much the same way as GLP-1, a hormone that is released from the intestine following a meal

While we are disappointed to discontinue the development of danuglipron, we remain committed to evaluating and advancing promising programs in an effort to bring innovative new medicines to patients, said Chris Boshoff, Pfizers chief scientific officer and head of R&D, in a statement

It is important to emphasize that the risk of eye problems appears primarily concentrated in patients with pre-existing diabetic retinopathy who experience rapid glycemic improvement