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Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels

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We did not confirm the findings from our pilot study of decreased creatine and GSH in pgACC in patients with ME/CFS

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However, it's the ones in the temporal region that can be dangerous...and they can and do co-exist with inflamed veins in other areas