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The ELISA has a reported 88% cross-reactivity with the GLP-1 (136) amide, 93% cross-reactivity with the GLP-1 (736) amide, and non-detectable cross reactivity with the glycine-extended GLP-1 (137) amide, the GLP-1 (737) amide, and exenatide

L-ascorbic acid requires a low pH (typically below 3.5) to remain stable, and that acidic environment can disrupt the copper complex in GHK-Cu, potentially degrading both ingredients

Thus, throughout the manuscript (as with GLP-1 glucoregulatory function above), we aim to highlight studies that directly examine endogenous gut peptide action via receptor knockdown or antagonism