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As a family medicine physician who is board certified in obesity medicine, Dr
It slows gastric emptying, suppresses glucagon secretion, and promotes satiety through direct brain signaling
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In addition, since iron is heterogeneously distributed across brain regions and cell types (Levi et al., 2024), potential off-target chelation could result in iron depletion in brain regions where iron supports physiological function and consequently affect neuronal and glial metabolism, neurotransmitter synthesis, or cell signaling
The SURMOUNT trials reported that approximately 4 to 7% of participants discontinued due to adverse events, depending on dose level
Discussion This review summarises: (1) appetite-related gut hormone changes after weight loss in people with overweight or obesity and (2) the differences among interventions involving CR, EX or their combination
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