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Despite the continuous improvement of detection and therapeutic methods, NSCLC is still difficult to diagnose and has a poor prognosis

The data from this registry demonstrates a survival advantage associated with intravenous A1AT administration, which develops independently and decoupled from the FEV1 decline (67)

Additional markers to consider: oxidative stress markers (8-isoprostane, malondialdehyde), inflammatory markers (hsCRP, IL-6), liver function tests

Oxidative stress results from an imbalance between the oxidative and antioxidant systems of cells and tissues, leading to the excessive production of oxidative free radicals and related reactive oxygen species (ROS) [11]

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Treatment is prescribed only when clinically appropriate, and individual results may vary