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Curr Med Chem

To avoid these limitations, targeted activation of the endogenous cellular antioxidant machinery has emerged as an alternative therapeutic strategy for the reduction of oxidative stress (Davis and Pennypacker 2017

reported outcomes are more plausibly indirect via recovery, routine adherence, and activity changes

This can shear the delicate peptide chains, damaging the molecules

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However, unlike Cys270, Cys199 is surface-exposed, which may fit the observation that about half of the SOT were retrieved in the recent persulfidome analyses