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doi: 10.1038/nature09646 76 CummingsJHPomareEWBranchWJNaylorCPMacfarlaneGT

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the long-term financial benefits are also noteworthy

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In patients with severe renal impairment (CLcr less than 30 mL/min/1.73 m2) not on hemodialysis, the recommended starting dosage is 5 mg once daily and should not exceed 10 mg once daily [see Warnings and Precautions (5.1) and Use in Specific Populations (8.6)]

When researchers pooled data across seven of these trials, the overall reduction held at 13%