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Hydroxocobalamin is the form typically used in intramuscular injections for treating B12 deficiency in the UK, as recommended by NICE guidelines

Furthermore, the relative abundance of Akkermansia , a genus positively associated with improvements in obesity-related metabolic issues 60 , was increased in the vehicle-treated group that underwent diet switch relative to the WD control group, suggesting a potential for distinct microbiome-mediated mechanisms of weight loss subsequent to diet switch from those of diet switch in combination with 5A-1MQ treatment

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Dose interruptions or reductions may be required for side effects (e.g., high hemoglobin, hypertension, bone pain)

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