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This is the most misunderstood concern surrounding GLP-1 therapy
In streptozotocin (STZ)-induced diabetic mice, renal capsule transplantation of these hydrogels doubled the normoglycaemic period and increased CD31 vascular density by 2.3-fold compared to Matrigel [170]
The GLP-1 agonists bind to receptors in the brain, pancreas and intestines, which helps to regulate insulin release, lower blood sugar levels, slow down digestion, and reduce appetite
Remarkably, there is evidence that GLP-1 agonists can enhance left ventricular ejection fraction, inotropy, coronary blood flow, cardiac output, and vascular endothelial function because of their cardiovascular effects and decrease overall cardiovascular event risks
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Thus, direct GLP-1R signaling in SPNs might have clinical relevance as it may account for increased heart rate, a common side effect of GLP-1R agonist medications 21
