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Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake

Preclinical and early phase clinical studies have demonstrated pharmacokinetic performance comparable to or exceeding conventional subcutaneous delivery for insulin, GLP-1 analogs, and selected therapeutic proteins, as well as enhanced immunogenicity for vaccines

Future trials should prioritize centrally penetrant molecules and incorporate biomarker driven, biologically enriched designs

It can help with heart health, too

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The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke