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NF-B is also considered to be a key transcription factor that drives aging by inducing changes that contribute to inflammatory responses, cellular senescence and SASP, and apoptotic signals [116]

Science 302 , 819822 (2003)

Fatigue can have many causes, including stress, poor sleep, hormone issues, nutritional deficiencies, or other medical concerns

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It should be noted that the cancer cells with abundant GSH also contain a high concentration of H 2 O 2 , resulting in DNA oxidative damage [10]

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