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The results showed a consistent advantage for the combination, and that advantage became more pronounced at higher weight loss thresholds, precisely where GLP-1 therapy tends to be most clinically meaningful: At a 20% weight loss threshold, 45% of women in the combination group achieved this level of loss, compared to 24% in the GLP-1 alone group

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Other first-generation GLP-1 medications include liraglutide, a synthetic form of the peptide with fatty acids attached for increased stability

The medication works by mimicking the incretin hormone GLP-1, which enhances insulin secretion, suppresses glucagon release, slows gastric emptying (though this effect may attenuate over time), and reduces appetite through central nervous system pathways

Stress-induced premature senescence or stress-induced senescence-like phenotype: one in vivo reality, two possible definitions

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