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2 Section of Nephrology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA

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The sublingual route may be simpler to prepare and administer than nasal spray but has its own challenges, including peptide degradation by salivary enzymes and the difficulty of keeping the solution under the tongue long enough for absorption

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the active form is the mature peptide consisting of 20-30 amino acids