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Semaglutide GLP-1 , Ozempic, Wegovy, and Mounjaro are all medications that have become increasingly popular in medical weight management
Beyond weight loss, GLP-1 RAs show promise for cardiovascular disease, dementia prevention, mast cells, and immune conditions
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Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]
These insights have driven the development of synthetic GLP-1R/GCGR co-agonists aimed at achieving long-term metabolic benefits
It can take time for the mind to catch up with changes in the body
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