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Besides cell death, ROS generated from oxidative stress also triggers SIPS

Toxic metals and oxidative stress part I: Mechanisms involved in metal-induced oxidative damage

In addition, both preclinical and clinical literature often underrepresent females, limiting insights into sex-specific immunometabolic and hormonal modulators of treatment response (Seyedinia et al., 2023

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More evidence that the scientific community is being more proactive at sniffing out misconduct is that the number of queries and allegations made to the US Office of Research Integrity nearly doubled between 1994 and 2011