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Sessions typically last 30-45 minutes Most patients describe the experience as relaxing and comfortable Theres no downtime
Nevertheless, fewer than half of patients treated with GLP-1RAs achieve guideline-recommended glycemic targets (typically HbA1c 10%), catabolic weight loss, and progressive -cell dysfunction 19
Some may be perfectly safe
In this Review, we discuss the progress made in the development of such modulators for the treatment of depression, and examine recent preclinical and translational studies that have investigated the mechanisms of action of glutamate-targeting antidepressants
They represent fundamentally different levels of efficacy
The major findings from these studies are summarized below
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