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Ghrelin induces adiposity in rodents. Nature , 407(6806), 908913
10.1152/physiolgenomics.00207.2007 42 FacchiniF.ChenY
These changes enhance its potency and extend its half-life to approximately 2030 hours, compared to the 1215 hours of native IGF-1
The strength of this insulin-driven hypersecretion of IGF-1 was shown in the past by the observation that hypoinsulinemia induced by prolonged fasting can completely normalize serum IGF-1 levels in acromegaly patients [36,37]
Results vary by individual, and no treatment is guaranteed to work for all patients.
