The Absorption Challenge The natural absorption of B12 involves a complex process: B12 from food binds to proteins and must be released by stomach acid It then attaches to intrinsic factor (a protein produced in the stomach) This complex travels to the small intestine where B12 is absorbed Finally, it enters the bloodstream for transport to cells This intricate pathway can be disrupted by numerous factors, including: Age-related decrease in stomach acid production Certain medications including proton pump inhibitors and metformin Gastrointestinal conditions like Crohn's disease Vegetarian or vegan diets with limited B12 sources Gastric bypass or other digestive surgeries Pernicious anaemia (autoimmune condition affecting intrinsic factor) The Injection Advantage B12 injections circumvent these potential absorption barriers by: Delivering B12 directly into muscle tissue Allowing immediate uptake into the bloodstream Bypassing the need for intrinsic factor and digestive processing Achieving higher blood concentrations than possible with oral supplements Providing 100% bioavailability regardless of digestive health This direct-delivery method explains why many people experience more noticeable benefits from injections compared to oral supplements
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At rest, your bicep is not promoting blood flow
There is no advantage to using the light sensitive forms of cobalamin, such as methylB 12 or adenosylB 12 , instead of the stable cyano or hydroxy forms, which are readily converted in the body into the coenzyme forms, methylB 12 and adenosylB 12
Wu CK, Fuh JL (2025) A 2025 update on treatment strategies for the Alzheimers disease spectrum
What spoiled B12 looks like A vial that is cloudy, discoloured, has visible particles or an unusual smell should not be used
