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5 Glucocorticoid-Induced fat metabolism disorder 5.1 Pathogenesis Obesity is a key feature of GC-induced metabolic syndrome [90] and also is a common feature of Cushings syndrome in patients receiving long-term GCs therapy [91, 92]

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Patients without Neurofibromatosis type 1 (NF1) tend to have better outcomes than those with NF1-associated MPNST, as NF1-related tumors are more likely to be multifocal, high-grade, and resistant to therapy (Evans et al., 2021)

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Endocrine 55 (1), 173178

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