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2024 Jul 25:11:100121

Muscle Mass and Glucagon-Like Peptide-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss

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Firstly, although we defined our inclusion criteria for anti-diabetic drug-nave patients as those who had not received any antidiabetic medication for at least three months (12 weeks), there might be some heterogeneity

The medication may be contaminated, mislabeled, improperly dosed, or entirely counterfeit

Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity