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doi: 10.2146/ajhp050459 48 SimonsenLHolstJJDeaconCF

Gwyer, D., Bhatt, D

doi: 10.1186/s13287-020-01689-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 142

Inhibition of the Xc- transport system by genetic (siRNA, CRISPR) or pharmacological means (Erastin, Sulfasalazine) impairs cystine transport and GSH synthesis, leading to the inactivation of GPX4 and induction of ferroptosis [14]