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Regarding the glucuronidation of morphine, two metabolites are formed, morphine-3-glucuronide, which is the major metabolite (45-55%) but inactive and morphine-6-glucuronide (20-30%), which is the more potent analgesic than its parent compound (Christrup, 1997)

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Modulation of TLR pathways, through agonists to boost antimicrobial defense or antagonists to dampen excessive inflammation, has emerged as a therapeutic strategy

week 4: P = 2.00 10 4

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doi: 10.1038/s41598-024-76832-w