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Key inclusion criteria for this trial included being aged 18 years or older, a body-mass index (BMI) of 30 kg/m 2 or more, or a BMI of 27 kg/m 2 or more and at least one prespecified obesity-related complication (hypertension, dyslipidaemia, obstructive sleep apnoea, or cardiovascular disease), and experiencing at least one unsuccessful dietary effort for weight reduction

However, this may happen during the first few weeks of the treatment or after a dose increase

diabetic ketoacidosis (leads to changes in blood pH)

Veneziano for helpful comments on this manuscript and import data analysis

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