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Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1

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As an experimental system we used a human BBB co-culture model improved by cARLA

Under zinc-deficient conditions, the downregulation of these genes mediated by the impaired function of Sp1 can lead to cell cycle arrest or abnormal cell cycle progression, ultimately affecting cell growth and proliferation [144, 145]

To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)